Esteban Cambiasso is out, while Fredy Guarin still has one foot out of the door, giving Walter Mazzarri fewer options in midfield.
The coach is expected to leave Javier Zanetti and Mateo Kovacic on the bench, while Saphir Taider and Zdravko Kuzmanovic will start.
The all-Argentinian attack will see Ricardo Alvarez supporting Diego Milito and Rodrigo Palacio.
Juventus had their winning streak ended at 12 league matches, and their loss in the cup along with the draw against Lazio may be the first sign of a drop in form. Still, the Bianconeri lost to the second best side in the country (conceding only one shot) and managed to draw an away match playing for 65 minutes in 10 men, so it's not all bad news for Conte's men.
Inter are struggling to get results both in the league and in the transfer market, while the club seems to be in a confused situation due to a lack of leadership and undefined roles in management positions. But as is Internazionale's tradition, this would make the perfect time to strike an unexpected result against historic rivals.
Juventus and Inter found a further reason to be on bad terms with the failed Guarin/Vucinic swap deal, but the current situation has one team firmly at the top of the league and their rivals barely managing to cling on to fifth position.
Moving to footballing matters, some absences will force Mazzarri to make some changes to his playing style, which could actually benefit Inter in creating a surprise element. The Bianconeri may now be required to put in extra effort to get back to winning ways, and Antonio Conte seems to be the perfect man for the job when it comes to motivation.
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