It was a nightmare start for Paulo Bento as Pepe was sent off and will face a suspension, while both Hugo Almeida and Fábio Coentrão were forced off through injury against Germany, with the latter's tournament now over.
Having played almost an hour with 10-men the coach may look to make changes to avoid fatigue, with the likes of William Carvalho and Hélder Postiga coming into contention.
Ricardo Costa and André Almeida will come into the starting backline, with goalkeeper Rui Patricio's place potentially under threat after a poor showing against Germany.
Portugal no doubt need the win more of these two sides so they are likely to try and play on the front foot from the start, though they will need to be wary on the counter given the key absentees in their backline.
USA will try to match their opponents' intensity early on but will sit deep knowing that a draw could yet be enough to see them through.
Bento will be hoping that Cristiano Ronaldo's fitness improves between now and the weekend as he could well be the decider against a team willing to be patient for their chances to break.
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