Manchester City crashed out of the FA Cup on Sunday and will be looking to make amends with the trip to Barcelona.
Martín Demichelis is suspended, while head coach Manuel Pellegrini will serve a touchline ban.
Matija Nastasic and Stevan Jovetic are both doubts.
Barcelona will be expected to secure their quarter-final place following their 2-0 win over Manchester City at the Etihad Stadium, despite succumbing to a disappointing 1-0 loss to Valladolid at the weekend.
City were defeated by Championship side Wigan in the FA Cup and will be looking to secure a positive result in Barcelona. However, they face an mountainous task to overcome the 2-goal deficit from the first-leg.
Despite their loss to Valladolid, the hosts are expected to pick up the win here.
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