Spurs have now lost their last 3 games and run the risk of seeing their season peter out, with Tim Sherwood needing a minor miracle to see his side progress.
The north London side face a defensive injury crisis, with no fit centre-backs. Tim Sherwood has admitted players will be fielded out of position.
Paulinho, Lloris and Adebayor haven't travelled, so it will be a severely weakened Spurs side out.
The tie is Benfica's to lose following their 3-1 win at White Hart Lane last week. The Portuguese side are unbeaten at home in the league and Europe this season and enter the fixture on the back of a 4-2 win over Nacional.
Spurs fell to a 1-0 defeat to Arsenal on Sunday, though with the pressure off, the team can play with more freedom. However, the chances of them breaking Benfica's home record this term is slim.
The hosts should have enough about them to compound the English side to a 4th successive defeat in all competitions.
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