Nigel Clough could reintroduce Lloyd Dyer and Jacob Davenport to the starting lineup as he looks to build on a solid 0-0 home draw with Bristol City on Saturday.
The visitors will once again be without defensive duo Ben Turner and John Brayford as they head to Bramall Lane.
With the play-off race hotting up, Sheffield United realistically need a win here to give them a realistic shot of catching up with Tony Pulis' in-form Middlesbrough side in 6th.
A water-tight defensive display on Saturday helped Burton pick up a point against Bristol City, however, Nigel Clough's men need to start turning draws into wins if they're to avoid the drop this season.
Burton will have one eye on Barnsley's clash with Norwich as they head to Bramall Lane on Tuesday night, but will likely struggle to pick up any points against who have won both of their last two home games.
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