Jaap Stam has a selection dilemma at the back, with Tom Holmes pushing for a start ahead of Tiago Ilori and Vito Mannone hoping to return to the starting XI after a two-game break.
Omar Richards will likely still be out, so Leandro Bacuna should retain his spot at right-back, with George Evans and John Swift battling for spaces in the midfield.
Joseph Mendes and Callum Harriott continue to build up fitness with the under-23s, while Garath McCleary, Jordan Obita and Stephen Quinn are all long-term absentees.
A defeat for Wolves on Saturday evening against Aston Villa has blown the title race wide open. The hosts have won just two of their last six and are now armed with a fragile three-point lead over Cardiff. Results on Tuesday night could see Wolves slip off the summit.
Reading put in a much better showing against Leeds than seen in recent months and will have felt aggrieved not to pick up all three points on Saturday afternoon. The Royals head to Molineux with just one win in 16.
Nuno Santo will be keen to ease worries of an end-of-season capitulation with a win over a Reading side scrapping for their lives down the other end of the table. You would expect the hosts to pick up the three points from this clash.
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