Gonul, Nukan and Tore are still out with long term injuries.
Andreas Beck was sold to Stuttgart during the international break so Adriano is expected to start at right-back.
New signing Negredo will almost certainly start on the bench as Tosun's form has been impressive, but fellow summer signing Lens might finally get his full debut ahead of Babel on the left.
Karabukspor is one of the most difficult away fixtures in the league. Their 3-1 win against Basaksehir was a great example of the counter-attacking style they have perfected over the years: tight defending, allowing the opposition to control the ball, but leaving them no space in their own half, and punishing them with a fast transition game, made possible by pacy wingers Torje and Depe.
Besiktas have collected seven points from three games, but their performances have not been impressive. Gonul's injury has exposed Gunes' team at the back and the summer signings, especially Negredo, are struggling to make an impact. They also face Porto in Portugal next Wednesday and even if Gunes does field his strongest side, players may find it hard to concentrate on this game.
Both teams have not lost so far this season, while Karabuk have not lost to Besiktas at home since 2014 and that run is likely to continue.
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