Dele Alli serves the third of his three-match ban on Tuesday night, but Jan Vertonghen returns after a one-match suspension.
His availability is a boost for Mauricio Pochettino, who may be without both left-backs Danny Rose and Ben Davies for the trip to Madrid, which could see Eric Dier drop into defence and Vertonghen start at left wing-back. Rose, though, has travelled to Madrid with the squad.
Pochettino will hope to have Mousa Dembele available for the Champions League tie, but the Spurs boss remains without Erik Lamela and Victor Wanyama, while Georges-Kevin Nkoudou is ruled out having suffered a concussion in the 1-0 win over Bournemouth.
Cristiano Ronaldo scored late on at the weekend to secure Real Madrid a fourth successive win. However, at the Bernabeu, Los Blancos have been far from their best, winning only two of their last five in front of their own fans.
Similarly, Tottenham have faltered on home turf this term, with Saturday's 1-0 win over Bournemouth their first in the league at Wembley, but have been in flying form away from home, winning all five competitive matches on the road, scoring 15 and conceding two.
These two last met in 2011 in the Champions League, with Real Madrid landing a 5-0 aggregate win and a 4-0 thumping of Spurs at the Bernabeu. A repeat may not be on the cards, but a stalemate is a possibility, despite Tottenham's defensive injury issues.
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