FC Basel played a 3-4-3 formation throughout the group stage of the Champions League but the loss of their best defender Manuel Akanji, who joined Borussia Dortmund in January, may force them into a back four.
Renato Steffen also moved to Germany during the winter break, but Valentin Stocker returned to the club in January and should play on the right instead.
Luca Zuffi is a doubt for the home side and may not recover in time for the first leg, while Germano Vailati is sidelined.
Leroy Sané and Fabian Delph were pictured in training ahead of Tuesday's match against Basel but it remains to be seen whether this match will come too soon for the duo.
David Silva failed to overcome injury in time to face Leicester on Saturday and remains a doubt for the away side here, although is expected to feature.
John Stones and Vincent Kompany will push for starts at centre-back after being named on the bench at the weekend, while Phil Foden is another option after making his comeback against the Foxes.
Danilo and Oleksandr Zinchenko battle for a starting role at left-back in Switzerland with Benjamin Mendy and Fabian Delph still sidelined.
This is Basel's third appearance in the Champions League round of 16. In the 2011/12 campaign they beat Bayern Munich 1-0 in the home leg before being trounced 7-0 in Germany.
Basel have already beaten one Manchester side this season, overcoming Manchester United 1-0 at home in December during the group stage.
However, Manchester City are firm favourites and Pep Guardiola will want to put the game to bed in Switzerland on Tuesday. Away from home, they have only won two of their last five in all competitions but it would be a real shock if they didn't beat Basel here.
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