Paul Pogba has been passed fit to play against Sevilla after missing Saturday's win over Liverpool and could replace Scott McTominay in the starting XI, in what should be the only change from the side that won at the weekend.
Jose Mourinho has confirmed Anthony Martial is available again after a two-game absence, while Zlatan Ibrahimovic also returned to first-team training on Monday.
Marouane Fellaini is an option again after coming on against Liverpool, but Ander Herrera, Phil Jones, Daley Blind and Marcos Rojo are sidelined. Jesse Lingard will serve a one-match European ban with his next booking.
Sevilla have confirmed Jesus Navas will miss Tuesday's trip to Old Trafford through injury. Sébastien Corchia is also sidelined, while Miguel Layún is ineligible.
Gabriel Mercado is expected to move out to right-back with Navas, Corchia and Layun unavailable. This will pave the way for Simon Kjaer to start at centre-back.
Few other changes are expected to the side that held Manchester United to a 0-0 draw in the first leg.
Sergio Escudero, Éver Banega and Gabriel Mercado are all a booking away from a one-match ban.
Manchester United could only manage a 0-0 draw away to Sevilla in the first leg but will hope to use home advantage to progress to the next stage of the Champions League. Under Jose Mourinho, United have only lost two home matches and both were against Manchester City.
Sevilla enter this match off the back of a 2-0 defeat at home to Valencia on Saturday. Away from home, the Spanish side have only lost one of their last six matches and they have scored in every European match this season.
United are usually very strong at home and Mourinho's side should do enough, buoyed by Saturday's win over Liverpool, to make the quarter finals of the Champions League.
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