Sergey Krivtsov has been sidelined since picking up an injury in the first leg and is expected to miss out here. Maksim Malyshev is also sidelined for the Ukrainian side.
Taison and Facundo Ferreya are a booking away from a ban.
Roma are behind in the tie but will hope to use the away goal they scored in Ukraine to overturn the 2-1 deficit on Tuesday. They have only won two of their last seven home matches in all competitions.
Shakhtar Donetsk have won their last five matches and have only failed to score in one of their last seven away matches - a 3-0 defeat to Napoli. While the goal they conceded on home soil could come back to haunt them, they are still very much in the tie.
Tuesday's second leg is evenly balanced but anything other than Roma progressing would be a surprise. Shakhtar have lost seven of their previous 10 matches away to Italian opposition.
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