Kevin De Bruyne was an unused substitute in Manchester City's 1-1 with Liverpool on Sunday but has not played since the start of August and was not picked by Belgium head coach Roberto Martinez for the international break.
Jan Vertonghen is also missing after sustaining a long-term injury for Tottenham, opening up a spot in Belgium's back three against Switzerland on Friday.
Michael Lang missed Switzerland's last internationals through injury but is available here and should start at right-back against Belgium. No other changes are expected from the away side on Friday night.
Belgium have won their last three matches and haven't conceded a goal in that time.
Switzerland won their first UEFA Nations League match 6-0 against Iceland.
The last match between the two sides finished 2-1 to Belgium in 2016 but it should be more comfortable for the Red Devils this time around.
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