Robin van Persie's withdrawal from the Dutch national squad through injury, despite completing the full 90 minutes against Aston Villa at the weekend, means that Klaas-Jan Huntelaar is all but guaranteed to start.
Young prospect Bas Dost will be hoping for his first international cap.
With Sneijder and Strootman out in midfield, van der Vaart could start in a deeper role alongside Nigel de Jong.
Germany manager Joachim Lowe has a long injury list to contend with, with no fewer than 7 players withdrawing from the squad after the weekend's action.
The leaves them without a number of big names, including Schweinsteiger, Ozil and Klose amongst others, and they join Sami Khedira on the sidelines.
Sven Bender, Sebastien Jung and Lewis Holtby have been called as cover.
This match will certainly mean more to Germany than it will to the Dutch, as they seek revenge for the 2-1 loss at Euro 2012 and the 3-0 friendly defeat prior to the tournament. With Germany significantly weakened by injuries, this match provides a good chance for Netherlands to get one over their rivals.
Germany's confidence may have taken a severe blow after their most recent result, as they threw away a 4-goal lead to draw 4-4 with Sweden. They have had a break since then but it could still prey on their minds.
On home soil, even without one of their talismanic strikers in Robin van Persie, the Dutch will want to take this opportunity to prove that they are a top team. Germany, when at full strength are quite simply the better side, but with their great many absentees, we could see an Oranje win.
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