Didier Drogba is a doubt for Chelsea after he missed the trip to Aston Villa at the weekend with a foot injury. However, he was an unused substitute in the first leg, with Fernando Torres impressing and setting up Saloman Kalou's crucial away goal, so Drogba may not have played anyway.
David Luiz is also a doubt with an ankle injury that forced him off at Villa Park at the weekend.
Roberto Di Matteo has suggested that he will rotate a few players in order to try and keep his squad fresh with a busy schedule ahead.
Cole, Luiz and Meireles are all one yellow card away from suspension.
Centre back Jardel looks likely to miss the game with an injury, so Miguel Vitor could come in.
Argentine Ezequiel Garay and Yannick Djalo both remain absent due to injury.
Benfica were without Pablo Aimar for the win over Braga at the weekend, but the playmaker could return to the starting XI, though young striker Rodrigo will also be pushing for a starting berth.
Benfica have no suspensions but have 5 first team players one yellow card away from incurring one.
Chelsea picked up a hugely impressive 1-0 victory at the Estadio da Luz in the first leg, with Saloman Kalou justifying Roberto Di Matteo's decision to select him by scoring the only goal of the game. Fernando Torres was also on form in that game and will hope that he can hit a run of form after a difficult first year at Chelsea. The atmosphere at Stamford Bridge is likely to be very lively, after the way Chelsea beat Napoli to make it through to this stage of the competition.
Benfica got back to winning ways against Braga at the weekend - a result that gives them a massive boost in the title race in the Portuguese league. However, they have relied heavily on their home form throughout the season in domestic competition and the Champions League and would have hoped to be taking a lead to London rather than be heading there having to score at least once, and most probably more. They have won only 2 of their 6 away games in the Champions League this season (including qualifiers), though they have scored in all of those games. They may well pick up a draw here, and the away goals will make Chelsea nervous and their crowd will be affected too. However, after the result in the first leg Chelsea should progress.
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