Phil Bardsley and Sebastian Larsson should both return to the line-up having missed the weekend's clash through illness, with the former likely to replace the injured John O'Shea at right-back.
Sessegnon made a goalscoring return from suspension and will keep his place while captain Lee Cattermole could make his comeback from a 4-match ban, though Colback and Vaughan both impressed in his absence.
The likes of Kyrgiakos and Bridge will continue to deputise at the back with Brown and Richardson sidelined.
Young midfielders Rodwell and Coleman will struggle to recover from injuries to start on Tuesday night, but could make the bench at The Stadium of Light.
Steven Pienaar is cup-tied, meaning Royston Drenthe could come in and represent the only change from an impressive 2-0 victory away at Swansea at the weekend.
Fellaini could, however, return to the starting line-up in place of Neville to partner Darron Gibson, who made his recovery from injury last time out. Neville would hope to revert to right-back in place of Hibbert if that were the case.
The game at Goodison Park between these two sides was a full-blooded affair, with Sunderland starting well to take the lead before tiring in the second half. You can expect the same commitment on Tuesday with a trip to Wembley at stake.
If Everton could pick up successive away wins with a victory, they know that they would face Liverpool in the semi-final in what would be a mouth watering derby, but winning at Sunderland is a tough task for any side.
The last three matches at The Stadium of Light between these two sides have all ended in draws, with another close encounter surely in the offing this could go right down to the wire, with extra time and penalties a possibility.
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