Frederic Antonetti is set to be without two key players for the visit of Evian.
Benoit Costil and Jean Makoun are both suspended after being sent-off in Rennes' dramatic win over PSG, Cheikh N'Diaye will take Costil's place at goalkeeper, while Vincent Pajot is likely to replace Makoun in midfield.
Victor Montano is out with a foot problem, and Abdoulaye Sane is expected to be absent with a thigh problem.
Evian have a slew of injury concerns going into this weekend's contest.
Jonathan Mensah is out due to a thigh injury, while Cedric Mongongu is unavailable due to similar problem.
Ali M'Madi, David Jarolim and Saber Khelifa are all still recovering from injuries and manager Pascal Dupraz will be expected to stick with a front three of Youssef Adnane, Kevin Berigaud and Sidney Govou.
Rennes and Evian meet at the Route de Lorient this weekend after picking up morale-boosting results last time out.
Frederic Antonetti's men pulled off one of the biggest surprises in recent history as they overcame big-spending Paris Saint-Germain despite being reduced to nine men. Meanwhile Evain produced a stirring comeback, pulling back a two goal deficit to earn a point against Saint-Etienne.
Mohammed Rabiu and Aldo Angoula were both on target in that game, and with Les Roses beginning to score goals from all areas of the field, they will go into a difficult game with renewed confidence.
However, it is at the back where the men from Annecy may struggle as they face a Rennes outfit that possesses a superb group of attacking players in Mevlut Erding, Jonathan Pitroipa, Romain Alessandrini and Julien Feret.
Expect a free-flowing attacking game that should be dominated by the home side. Les Rouge-et-Noir have won four of their last five and should be able to sweep past Evian and maintain their title challenge.
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