Andre Wisdom is now fully fit and could take the place of makeshift full-back Stewart Downing, who fell asleep at the back post for Tottenham's opener in midweek.
Elsewhere Sahin and Shelvey will both hope to start ahead of Henderson after the midfielder failed to take his chance against Spurs. However, there is also a welcome return from Lucas, who Rodgers has confirmed will be part of the squad.
Suso and Assaidi are also both in competition to put pressure on Raheem Sterling, who could be rested having played a lot of first team action in the league this season.
Nigel Adkins has no fresh injury concerns so is unlikely to make changes to a side that has picked up 8 points from a possible 12.
One possible change could see veteran keeper Kelvin Davies return in place of Gazzaniga, who has made costly errors in recent matches.
Teenager Luke Shaw should keep his place at left back though Danny Fox could return from a knee injury, while Richardson is likely to remain sidelined.
Such is Liverpool's league plight that a win for Southampton at Anfield would move the Saints within one point of Brendan Rodgers' side, with Adkins masterminding a 4-game unbeaten run following calls for his head from certain sections of the support.
Though they haven't met in the league since 2005, Southampton managed to win 3 of the last 4 matches between the two sides, though an in form Luis Suarez is likely to be more than capable of punishing opposition errors if Southampton continue to defend in the same vein.
There should be plenty of goals in this one, despite the Reds' dependency on Suarez to get them. The home side's second top goal contributor has been an opponent this season, with 3 own goals to their name, while Southampton have scored the most own goals in the league (also 3).
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