Benitez favoured compatriot Romeu over Mikel in midweek and could do so once again, while he will be forced into a change at the back with David Luiz picking up a fifth booking of the season, so Cahill will start.
Juan Mata should return to the starting XI at the expense of the ineffective Ryan Bertrand from the side that drew with Fulham.
Fernando Torres should continue to lead the line with Sturridge set to miss out through injury once again, while Moses and Marin will hope to feature at some point.
Chelsea fans know that without a goalscorer they have no chance of mounting a title challenge so will hope that Torres can reboot his season against a West Ham having scored 6 goals in 6 games against the Hammers in the past, including his first ever for Chelsea.
West Ham haven't scored more than once in a game against Chelsea in their last 13 attempts (8 goals in that time) but face a Blues side yet to fire under Benitez having mustered just 4 shots on target in two games under the Spaniard.
All the signs point to a tight, low-scoring game, with the pressure certainly on Chelsea's new interim boss to get a first win under his belt. The Hammers have won just 1 of their last 6 will do well to add another here.
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