Osasuna remain rooted to the foot of the table after a hugely disappointing 1-0 home defeat to Valladolid last weekend.
Los Rojillos have also been hit by a raft of injuries that, amongst others, will keep Roland Lamah and Patxi Punal out, so Anthony Annan should return in midfield and Sisi will keep his place in the side.
Ruben is suspended after he was sent-off last week so Lolo will also return in defence.
Despite Espanyol's run of seven points from three games both these sides remain in the bottom three and Osasuna are in dire need of points to avoid being cut further adrift at the bottom.
Jose Luis Mendilibar's side however have been dire away from home this season with five defeats from five and without Punal and Lamah the task could be too much for them.
Sanchez's return to the Espanyol team could also be a key factor as he has linked excellently with Joan Verdu throughout the first quarter of the campaign.
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