Barcelona could be handed a huge boost for the visit of city rivals Espanyol as Tito Vilanova could return to the bench less than three weeks after having surgery to remove a cancerous tumour on his parotid gland.
Cesc Fabregas could also return after recovering from a hamstring injury, with Andres Iniesta moving forward to replace Alexis Sanchez in the frontline.
Carles Puyol may also return to the heart of the defence after being rested for the 3-1 victory over Valladolid.
Espanyol meanwhile remain unbeaten in four games under Javier Aguirre after claiming their first win under the Mexican last time out against Deportivo la Coruna.
Aguirre will be forced into at least one change from that match though as Mubarak Wakaso is away on international duty with Ghana, so Cristian Alfonso is likely to deputise on the right side of midfield.
Espanyol always seem to raise their game and make things difficult for Barca in the derby, but the league leaders have been on such fantastic form it is hard to see Los Pericos extending their unbeaten run under Aguirre to five games.
The Camp Nou will be even more emotional than ever on derby night with the return of Vilanova and it would seem a fitting tribute for his players to reward their coach with their 16th victory from 17 league games this season.
WhoScored.com provides you with unparalleled football statistics, as well as detailed football previews and football rankings from competitions all over the world. Our live, in-depth football statistics from the Premier League, La Liga, Serie A, Bundesliga, Ligue 1, Eredivisie, Russian Premier League, Brasileirão, MLS, Super Lig and Championship supplies unique and original insights for football fans, sports betting punters, journalists, football managers and players. We also have football tables, live scores, top performing players as calculated with our unique WhoScored.com ratings, articles, graphics, rankings and much more.