Winger Ryan Babel has joined Sigthorsson and Boilesen on the sidelines and so all three will miss the trip to the Bernabeu.
That could mean a start for Derk Boerrigter on the wing, with Christian Eriksen continuing in the 'false 9' role up front.
Thus, Babel aside, Ajax could field the same team that so nearly won at Manchester City last time out.
Although Real are already guaranteed 2nd place in the group, Jose Mourinho is likely to want to avoid defeat here, as a loss here would mean this campaign is the worst Real Madrid have ever done in a Champions League group stage.
Nonetheless, Mourinho will not want any players to be risked or injured unnecessarily so we could see a much-weakened home team, while the Dutch side will come here with every intention of going for gold.
While they will be hoping that City slip up in Germany, Ajax will know that an unlikely victory here would mean they qualify for the Europa League knockout stages and they will be keen to do that. They have a terrible record against Real, though, having lost their last 5 meetings conceding 16 goals, and a win might just be too much to ask of them.
WhoScored.com provides you with unparalleled football statistics, as well as detailed football previews and football rankings from competitions all over the world. Our live, in-depth football statistics from the Premier League, La Liga, Serie A, Bundesliga, Ligue 1, Eredivisie, Russian Premier League, Brasileirão, MLS, Super Lig and Championship supplies unique and original insights for football fans, sports betting punters, journalists, football managers and players. We also have football tables, live scores, top performing players as calculated with our unique WhoScored.com ratings, articles, graphics, rankings and much more.