Claudio Marchisio is suspended having picked up 3 yellow cards in his last 3 Champions League games, so former United youngster Paul Pogba should come into the midfield.
The only other selection debate, with a fully fit squad to choose from, is likely to be who starts up front, with Vucinic, Quagliarella and Giovinco competing for two places in the side.
Lichtsteiner and Asamoah will continue to be favoured as the two starting wing-backs.
With Shakhtar already qualified, Juventus know that they only need a point to ensure their progression to the final 16, and the Italian champions will be meticulously drilled to ensure that they do not lose this match.
The hosts also know that a point here will see them top the group, so may be a little more reserved than usual, with Fernandinho and Pirlo likely to see plenty of the ball in what could be a patient start to the game.
In what is likely to be a tactical battle, with two very different formations on display, this match should be an intriguing one, though the circumstances may see the match fizzle out toward the end, with both sides more keen to avoid defeat than actually win.
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