Sir Alex Ferguson is likely to make a raft of changes to the side that won at Reading with the Red Devils already assured of top spot in Group H.
With the likes of Anderson, Nani, Kagawa and Valencia all sidelined, however, his options in midfield are slim, so Powell is likely to start with Giggs set to bring the experience in the middle of the park.
At the back Jones, Smalling and Buttner are all certain to start, while the game is likely to come too soon for returning captain Nemanja Vidic.
Cluj have the likes of Ciprian Deac and Adam Vass back from injury but neither were named in their Champions League squad due to long term absences, so both are ineligible here.
Bakary Sare and Ronny will remain sidelined for some time, so there will be very few changes to the side that beat Braga last time out.
Up front Bastos, supported by hat-trick hero from the last round Rui Pedro, should lead the line ahead of Kapetanos, who opened the scoring the last time these sides met.
The Romanian outfit have far more to play for in this fixture, with any result better than that of Galatasaray, who play Braga in the other game in Group H, enough to see them qualify for the last 16.
In contrast United will use the game to get a number of players back to full fitness, particularly at the back, so may be a little shaky to start as they settle back into first team action.
The visitors will look to exploit this, and the fact that the home side have conceded a lot of early goals this season, to get their noses in front but United should have enough quality in their squad to get a result.
WhoScored.com provides you with unparalleled football statistics, as well as detailed football previews and football rankings from competitions all over the world. Our live, in-depth football statistics from the Premier League, La Liga, Serie A, Bundesliga, Ligue 1, Eredivisie, Russian Premier League, Brasileirão, MLS, Super Lig and Championship supplies unique and original insights for football fans, sports betting punters, journalists, football managers and players. We also have football tables, live scores, top performing players as calculated with our unique WhoScored.com ratings, articles, graphics, rankings and much more.