Andrea Stramaccioni will make wholesale changes to his side for the Europa League visit of Rubin Kazan. It is more or less a second team that will play in this game, and that may be the case for much of the EL group stage for inter.
Youngster Marko Livaja will start up front between Coutinho and Cassano.
At centre-back, Matias Silvestre should return, and he could play alongside Walter Samuel, though Juan Jesus could retain his place after a man of the match performance at the weekend.
Rubin have made significant additions to their squad in recent times, with the likes of Gokhan Tore and Ivan Marcano arriving in the summer. Tore, however, is unlikely to feature, with Kasaev and Karadeniz occupying the wide spots.
Rubin have little to worry about with regards to injuries and have many options all over the pitch as a result.
Salomon Rondon will lead the line on his own, ahead of Dydyun in the central attacking midfield position.
Inter have started the season fairly brightly, with 2 wins from their opening 3 league fixtures, and new signings fitting in together well from the get-go. Antonio Cassano will be a great purchase for them, and he will once again play his part here.
Having won 3 of their first 4 league games, Rubin have slumped to 3 losses in the last 4 and thus sit down in 8th (out of 16) in the Russian top flight.
Rubin Kazan should in no way be underestimated by the home side. They are regulars in European competition these days and, most memorably, pulled off a magnificent win at Camp Nou just a couple of seasons ago. However, given their recent form, and Inter's home advantage, the Italians should just about scrape by.
WhoScored.com provides you with unparalleled football statistics, as well as detailed football previews and football rankings from competitions all over the world. Our live, in-depth football statistics from the Premier League, La Liga, Serie A, Bundesliga, Ligue 1, Eredivisie, Russian Premier League, Brasileirão, MLS, Super Lig and Championship supplies unique and original insights for football fans, sports betting punters, journalists, football managers and players. We also have football tables, live scores, top performing players as calculated with our unique WhoScored.com ratings, articles, graphics, rankings and much more.