Mousa Dembele has returned to training at Spurs after a rather lengthy lay off due to a hip injury. He did not require surgery, and has a 50% chance of playing here in Italy, though he may be saved for the Premier League clash with West Ham on Sunday.
Emmanuel Adebayor will likely start given that he will start serving a 3 game suspension in domestic competition for his sending off against Arsenal at the weekend.
Steven Caulker is a doubt with the same injury that kept him out of the north London derby on Saturday.
The top two teams in group J face off in Rome with either side able to book their progress to the next round, though that is dependent on the result in the other game for Tottenham.
Both sides remain unbeaten in the group but have drawn 5 games between them, including their goalless stalemate at White Hart Lane. Spurs in particular, have clearly found it hard to motivate their better players on a Thursday night, and will need to improve in the competition if they are to go as far as Andre Villas-Boas has claimed they want to.
Lazio will be favourites given their home advantage, and although Spurs were probably just about the better side when these sides met in September, Lazio gave a good account of themselves, and in their own back yard, they should just about edge it
WhoScored.com provides you with unparalleled football statistics, as well as detailed football previews and football rankings from competitions all over the world. Our live, in-depth football statistics from the Premier League, La Liga, Serie A, Bundesliga, Ligue 1, Eredivisie, Russian Premier League, Brasileirão, MLS, Super Lig and Championship supplies unique and original insights for football fans, sports betting punters, journalists, football managers and players. We also have football tables, live scores, top performing players as calculated with our unique WhoScored.com ratings, articles, graphics, rankings and much more.