The Jong Oranje soared to the summit of Group B following the 5-1 thumping of Russia and head coach Cor Pot has confirmed he won't be making wholesale changes from his starting XI.
However, the Netherlands will likely bring in one or two fresh faces, with Jordy Clase and Florian Jozefzoon tipped to begin the encounter from the off at the expense of Marco van Ginkel and Georginio Wijnaldum.
With both teams already guaranteed a place in the semi-finals, the pressure is off Spain and the Netherlands, with minor changes anticipated from either side.
However, while the pairing will be prepared to take the encounter lightly, the runner up in Group B will likely come up against Italy in the next round, barring a Norway victory against the Azzurri on Tuesday evening.
Morata is pushing for a start after his second goal in as many games - the striker has been in the field of play for just 44 minutes in the competition and will be hoping for an inclusion in the Spain starting XI.
The Netherlands are without any injury concerns, but Cor Pot may look to freshen his squad up, meaning the highly rated Jordy Clasie could be handed a first team spot.
Spain must win if they're to secure top spot in Group B, with the Jong Oranje's superior goal difference meaning a draw will see them finish second.
Julen Lopetegui's side have won seven of the last 11 competitive meetings between the two teams and four of the last five and while Spain will be looking for the win, a draw is the likely outcome.
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