Following a successful African Cup of Nations both John Obi Mikel and Victor Moses could be in line to return to the Chelsea teamsheet.
The duo could therefore give the likes of Lampard and Mata a break, while Ashley Cole could also get a rest with Ryan Bertrand his replacement.
With John Terry still struggling with a knee injury and David Luiz suspended, the centre-back pairing will be Ivanovic and Cahill, while Marko Marin will hope for a rare start having opened his league account for the Blues at the weekend.
With only an FA Cup replay against Brentford to concern them on Sunday, Rafa Benitez should name a strong line-up, looking to get an advantage to take back to the Bridge in order to rest some key players in a more challenging period.
Sparta Prague will be keen to avoid defeat to keep the tie alive and may look to contain the visitors attacking threat in turn with a defensive shape.
The Blues should have enough to come away with a victory and put themselves in the driving seat ahead of the second leg, with a potential clash against Ajax in the pipeline.
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