Brendan Rodgers fielded a strong lineup for the first leg of this tie and is likely to do so again as his team go in search of the 2-0 win they need as a minimum in order to stand any chance of progressing.
With Fabio Borini out for the rest of the season with a dislocated shoulder and both Sturridge and Coutinho cup-tied, Liverpool are looking rather threadbare in attack.
Martin Skrtel is a doubt with a knee injury, so Agger could play.
Steven Gerrard has proven he doesn't need resting as the only ever present midfielder or attacker in the Premier League this season, and he will play once again here, probably alongside Joe Allen in defensive midfield, though Gerrard's attacking impetus will certainly be needed.
Luciano Spalletti could choose to field the same starting XI that beat Liverpool fairly comfortably in the first leg.
Vladimir Bystrov serves the final game of his 3 match ban in European competition for his red card against Malaga on matchday 5 in the Champions League group stages.
Sergei Semak will be hoping to start after coming off the bench to score the second goal last week.
Liverpool face an uphill task if they are to overturn the two goal deficit inflicted on them in the first leg of this Europa League tie, but this is the only competition they remain in with any (albeit very little) chance of winning, so they have no choice but to go for broke.
Zenit showed no sign of rustiness after a long winter break and started very brightly against Liverpool. Liverpool had a long journey for that game, though, and Zenit may struggle to get going quite so quickly this time around.
Liverpool could pick up a win but as they commit men forwards they will leave space at the back that the attacking talents of Hulk, Kerzhakov and co. could exploit. The home side will be confident after their 5-0 victory over Swansea last weekend but this will be a wholly different match.
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