Jordi Alba is suspended having picked up his third yellow card of the tournament in the reverse fixture, and he is likely to be replaced by Adriano, who returns from a ban.
Tito Vilanova would have liked to keep Messi fresh ahead of Wednesday's game but was forced to introduce the Argentine with the side trailing to Bilbao at the weekend. It took Messi just 8 minutes to score from the bench but Barca could only draw the game.
Cesc Fabregas, David Villa, Alexis Sanchez and Pedro compete for two places in the starting XI, with the former's inclusion potentially pushing Iniesta forward into the front three, though Busquets is sidelined with a pelvic injury.
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