Uruguay's impressive dismantling of Tahiti ensured their place in the semi finals, with the 8-0 win over the French Polynesian side enough to finish second in Group B.
Óscar Tabárez will be expected to ring the changes once again, especially on the frontline where Edinson Cavani and Luis Suárez, the latter netting twice from the substitute bench, look set to be recalled to the starting XI.
Abel Hernández will be pushing for a start following his four goal haul against Tahiti, but Diego Forlán is likely to be recalled to the starting XI.
Andrés Scotti is suspended following his red card on Sunday evening.
A repeat of the 1950 World Cup final and Brazil will be determined to ensure the same scoreline isn't replicated at the Estadio Mineirão when the two teams meet on Wednesday evening.
Brazil head coach Luis Felipe Scolari will be expected to make two changes from the side that overcame Italy, with Paulinho and Dante coming in for Hernanes and David Luiz.
Neymar was substituted with 20 minutes remaining in the victory over the Azzurri and will be set to retain his starting place, hopeful of netting his fourth goal in four Confederations Cup games.
Uruguay will be looking to spring an upset over their South American rivals as they aim to replicate their feat from 1950.
Abel Hernández looks set to drop to the bench for the encounter, despite his impressive display against Tahiti, as Óscar Tabárez looks set to revert back to 4-3-3 for the meeting with the hosts.
Diego Forlán, Luis Suárez and Edinson Cavani are ready to come back into the starting XI after the latter completely sat out the 8-0 win on Sunday evening and will be aiming to improve his poor international goalscoring record of just 14 goals in 52 appearances.
While Uruguay will be aiming to navigate their way past the semi finals, home advantage and the strength of Brazil's attack line will see the hosts through to the final.
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