Sergio Busquets returns after serving his ban, but injury may prevent him from playing. The midfielder was, as of Wednesday, training by himself.
Neymar and Jordi Alba remain out with injury. Gerard Pique is nearing a return, but he's likely to be ruled out of this game.
Marc Bartra and Javier Mascherano are both struggling with minor injuries, but Tata Martino will be waiting until the last minute for them to prove their fitness.
Barcelona's only hope for glory is in La Liga and their win over over Athletic Bilbao last weekend enabled them to keep their title bid on track. But, with a number of injuries affecting the squad and what could be labelled a crisis in defence regarding player availability, Tata Martino has his work cut out in selecting his first XI.
Barca were not at their vintage best last weekend, but they were much better than they had been in previous weeks. Importantly, Lionel Messi got back to scoring ways and showed glimpses of his best form.
El Madrigal is not an easy place to go and Barca know this - their last visit in 2012 saw them frustrated in a game that ended goalless. With Villarreal chasing a European place, a similar result is likely this time round.
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