Juan Antonio Pizzi has an injury crisis in defence, with Ricardo Costa injured and Jeremy Mathieu a doubt. Diego Alves is also expected to miss out with a hamstring problem.
Víctor Ruiz however is available and should partner Philippe Senderos at centre-back.
Pizzi could also utilise a more conservative 4-2-3-1 to help stifle the Sevilla attack.
Sevilla have lost just the once at home in the Europa League this season and will be looking to continue their fine European form at the Ramón Sánchez Pizjuán Stadium. While the hosts go in hunt of a top-4 finish, Unai Emery is likely to challenge his side to secure silverware in his first full season at the helm.
Valencia's progress to the semi-final stage has been far more tumultuous compared to their league counterparts having emphatically progressed to this stage following an exciting 5-3 aggregate win over Basel. Pizzi will be wary of Sevilla's, at times, fluid attack and may opt for a more defensive approach to take a positive result into the second leg next week.
The visitors have a number of injury concerns at the back and Sevilla will look to capitalise through the impressive Ivan Rakitic and Carlos Bacca. Emery's side should have enough about them to secure a first-leg win.
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