Coke will be expected to start having missed the first leg as he was suspended.
Ivan Rakitic started from the bench in the weekend defeat to Athletic, but should come back into the starting XI here.
Sebastián Cristóforo and Cicinho are sidelined through injury, while Denis Cheryshev and Diego Perotti will be assessed closer to kick off.
Valencia face an uphill task of overcoming a two-goal deficit at home to Sevilla, though they have been in this position before having been 3-0 down from the first leg against Basel, before winning the tie 5-3 at the Mestalla.
Sevilla's Champions League hopes suffered a real blow with the 3-1 loss in Bilbao at the weekend, but having rested players for the league encounter, Unai Emery is set to name his strongest possible XI for the trip to Valencia.
Valencia will be buoyed by the return of Ricardo Costa and should be able to secure the win here, but Sevilla have the quality in attack to net at least once and should progress to the final on the away goal ruling.
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