Miroslav Klose will likely drop to the bench following an underwhelming performance against France.
André Schürrle may get the nod ahead of Mario Götze to start in the attack alongside Mesut Özil and Thomas Müller.
Joachim Löw is expected to persist with the same defence which comfortably held France on Friday, meaning Per Mertesacker will be forced to settle for a spot on the bench.
Shkodran Mustafi is injured and will miss out.
Brazil progressed to the semi-final of the World Cup with an impressive 2-1 win over Colombia, despite many feeling the hosts would crash out at the expense of their South American counterparts on Friday evening.
Goals from Thiago Silva and David Luiz saw them secure victory, though the former is suspended having picked up his second yellow card of the competition.
The bigger blow though will come in the absence of Neymar, who is out for the rest of the tournament due to a back injury following a collision with Juan Zuñiga, though that may spur the Brazil team on to secure their 6th World Cup.
Germany haven't lit up the competition as people may have expected, but have done enough to progress to this stage of the tournament.
The win over France will have filled the team with confidence and they certainly have the strength in depth to win the competition.
With both Neymar and Thiago Silva out, Germany will look to capitalise on the absence of the duo and secure a place in the final.
WhoScored.com provides you with unparalleled football statistics, as well as detailed football previews and football rankings from competitions all over the world. Our live, in-depth football statistics from the Premier League, La Liga, Serie A, Bundesliga, Ligue 1, Eredivisie, Russian Premier League, Brasileirão, MLS, Super Lig and Championship supplies unique and original insights for football fans, sports betting punters, journalists, football managers and players. We also have football tables, live scores, top performing players as calculated with our unique WhoScored.com ratings, articles, graphics, rankings and much more.